ActiTide™ NP1 / Nonapeptide-1

Short Description:

Alpha-Melanocyte-Stimulating Hormone (α-MSH), a 13-amino acid peptide, binds to its receptor (MC1R) to activate the melanin pathway, resulting in increased melanin production and darker skin. ActiTide™ NP1, a biomimetic peptide designed to mimic the sequence of α-MSH, competitively inhibits the binding of α-MSH to its receptor. By blocking the activation of the melanin pathway at its source, ActiTide™ NP1 reduces melanin synthesis and exhibits skin-brightening efficacy.

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Product Detail

Product Tags

Brand name	ActiTide™ NP1
CAS No.	/
INCI Name	Nonapeptide-1
Application	Mask series, Cream series, Serum series
Package	100g/bottle, 1kg/bag
Appearance	White to off-white powder
Peptide content	80.0 min
Solubility	Soluble in water
Function	Peptide series
Shelf life	2 year
Storage	Should be stored at 2~8°C in a tightly closed container
Dosage	0.005%-0.05%

Application

Core Positioning

ActiTide™ NP1 is a powerful whitening agent that targets the very initial stage of the skin-darkening process. By interfering with melanin production at its source, it delivers high-efficacy skin tone control and reduces the appearance of brown spots.

Core Mechanism of Action

1. Source Intervention: Inhibits Melanogenesis Activation Signals Blocks the binding of α-melanocyte-stimulating hormone (α-MSH) to the MC1R receptor on melanocytes.

This directly severs the “initiation signal” for melanin production, halting the subsequent synthesis process at its source.

2. Process Inhibition: Prevents Tyrosinase Activation Further inhibits the activation of tyrosinase, a key enzyme critical to melanin synthesis.

This action blocks the core process of melanogenesis to more effectively combat skin dullness and prevent the formation of brown spots.

3. Output Control: Prevents Excessive Melanin Production Through the dual mechanisms above.

It ultimately ensures precise control over the “overproduction” of melanin, preventing uneven skin tone and the worsening of hyperpigmentation.

Formulation Addition Guidelines

To preserve the ingredient’s activity and avoid prolonged exposure to high temperatures, it is recommended to add ActiTide™ NP1 in the final cooling phase of formulation. The system temperature should be below 40°C at the time of incorporation.