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Product Paramete

Trade name	UniAPI-PBS
CAS	1405-20-5
Product Name	Polymyxin B sulfate
Appearance	White or almost white powder
Solubility	Water soluble
Application	Medicine
Assay	The sum of polymyxin B1, B2, B3 and B1-I: 80.0% minPolymyxin B3: 6.0% maxPolymyxin B1-I: 15.0% max
Package	1kg net per aluminum can
Shelf life	2 years
Storage	Store in cool and dry place, away from light. 2~8℃ for storage.
Chemical Structure

Application

Polyxin B sulfate is a cationic surfactant antibiotic, a mixture of polyxin B1 and B2, which can improve the permeability of cell membrane. Almost odourless. Sensitive to light. Hygroscopic. Soluble in water, slightly soluble in ethanol.

Clinical effect

Its antibacterial spectrum and clinical application are similar to polymyxin e. it has inhibitory or bactericidal effects on Gram-negative bacteria, such as Escherichia coli, Pseudomonas aeruginosa, paraescherichia coli, Klebsiella pneumoniae, acidophilus, pertussis and dysentery. Clinically, it is mainly used for infection caused by sensitive bacteria, urinary system infection caused by Pseudomonas aeruginosa, eye, trachea, meningitis, sepsis, burn infection, skin and mucous membrane infection, etc

pharmacological action

It has antibacterial effect on Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Haemophilus, enterobacter, Salmonella, Shigella, pertussis, pasteurella and Vibrio. Proteus, Neisseria, Serratia, pruvidens, Gram-positive bacteria and obligate anaerobes were not sensitive to these drugs. There was cross resistance between this drug and polymyxin E, but there was no cross resistance between this drug and other antibiotics.

It is mainly used for wound, urinary tract, eye, ear, trachea infection caused by Pseudomonas aeruginosa and other Pseudomonas. It can also be used for sepsis and peritonitis.