PromaCare G-Glucan (5-8 million Da) / Galactoglucan

Short Description:

Galactoglucan is a long-chain polymer of monosaccharides linked by glycosidic bonds, typically existing as levorotatory structures. Derived from microbial fermentation, it features high purity, GRAS certification, and non-toxicity via comprehensive safety tests, while specifically binding to cell receptors such as Dectin-1 and TLRs to exert multifunctional effects—strengthening the skin barrier by boosting FLG and LOR expression, alleviating inflammation through inhibiting pro-inflammatory factors and promoting anti-inflammatory cytokines, and combating aging via regulating the NRF2 pathway and stimulating collagen. PromaCare G-Glucan (5-8 million Da) is mainly applied in the field of skin microecology regulation.

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Product Detail

Product Tags

Brand name:	PromaCare G-Glucan (5-8 million Da)
CAS No.:	120112-82-5
INCI Name:	Galactoglucan
Application:	Toner; Lotion; Cream; Serum; Mask
Package:	100g/bottle
Appearance:	White to off-white powder
Function:	Anti-aging; Antioxidant; Moisturizing
pH value (25°C, 0.1% solution):	5.5 – 8.0
Shelf life	24 months
Storage:	Keep container tightly closed and in a cool place. Keep away from heat.
Dosage:	0.5 – 5.0%

Application:

PromaCare G-Glucan is a high-purity (>90%), naturally derived L-β-galactoglucan, a highly branched complex polysaccharide polymer.
Composed of glucose and galactose units, it features a stable single-, double-, and triple-helix conformational structure. Its unique left-handed configuration and multi-helix architecture confer strong biological recognition capability and receptor-binding activity.
PromaCare G-Glucan is naturally water-soluble without chemical modification and maintains excellent stability across a wide pH range and temperature conditions. It is safe, mild, and non-toxic, suitable for various skin care applications.

Mechanism of Action:

PromaCare G-Glucan exerts its biological effects through multi-target receptor recognition mechanisms:
1. Specific binding to C-type lectin receptor Dectin-1
2. Modulation of Calcium-Sensing Receptor (CaSR) related signaling pathways
3. Targeting galectin family proteins such as Galectin-3
4. Interaction with pattern recognition receptors including CR3, TLR2/4, and scavenger receptors
Through coordinated multi-receptor regulation, it activates intracellular signaling cascades, modulates inflammatory responses and immune pathways, and regulates barrier-related protein expression, contributing to skin repair and photo-protection.

Key Benefits:

1. Skin Barrier Repair & Strengthening
Enhances expression of key barrier structural proteins
Reinforces stratum corneum integrity
Reduces transepidermal water loss (TEWL)
Promotes keratinocyte migration
Improves compromised skin barrier function
2. Accelerated Skin Recovery
Supports wound healing processes
Regulates inflammatory microenvironment
3. Photo-Damage Protection & Anti-Photoaging
Inhibits UV-induced pro-inflammatory mediators
Reduces oxidative stress
Protects keratinocytes against UVB damage
4. Antioxidant & Anti-Aging Support
Regulates antioxidant pathways (e.g., NRF2)
Promotes collagen synthesis
Improves skin firmness and elasticity