ActiTide-AT2 / Acetyl Tetrapeptide-2

Short Description:

ActiTide-AT2 activates the glycoproteins FBLN5 and LOXL1, which are essential components for maintaining the normal structure and function of elastin fibers. It also can upregulate the gene expression associated with collagen synthesis and focal adhesion, inducing the synthesis of elastin and type I collagen, thereby increasing skin firmness and rebuilding the epidermal structure. It is suitable for firming and anti-aging products for the face and body.


Product Detail

Product Tags

Brand name ActiTide-AT2
CAS No. 757942-88-4
INCI Name Acetyl Tetrapeptide-2
Application Lotion, Serums, Mask, Facial cleanser
Package 100g/bottle
Appearance White to off-white powder
Solubility Water soluble
Function Peptide series
Shelf life 2 years
Storage Store the container tightly closed in a cool, dry place at 2 - 8°C.
Dosage 0.001-0.1% below 45 °C

Application

In terms of anti – inflammation, ActiTide-AT2 can stimulate the skin’s immune defenses, helping to maintain skin health.

For depigmenting and lightening effects, ActiTide-AT2 works by inhibiting the activity of tyrosinase, which is an enzyme crucial for melanin production. This action helps to reduce the visibility of brown spots.
Regarding skin firming and plumping, ActiTide-AT2 promotes the production of Type I collagen and functional elastin. This helps to compensate for the loss of these proteins and prevent their degradation by interfering with the enzymatic processes that break them down, such as metalloproteinases.
As for skin regeneration, ActiTide-AT2 increases the proliferation of epidermal keratinocytes. This strengthens the skin’s barrier function against external factors and prevents water loss. Additionally, the Acetyl Tetrapeptide – 2 in ActiTide-AT2 helps fight sagginess by enhancing key elements involved in elastin assembly and the overexpression of genes related to cellular adhesion. It also induces the expression of proteins Fibulin 5 and Lysyl Oxidase – Like 1, which contribute to the organization of elastic fibres. Furthermore, it upregulates key genes involved in cellular cohesion through focal adhesions, such as talin, zyxin, and integrins. Most importantly, it promotes the synthesis of elastin and collagen I.

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