RJMPDRN® REC represents a significant advancement in nucleic acid-based cosmetic ingredients, offering a recombinant salmon PDRN synthesized through biotechnology. Traditional PDRN is primarily extracted from salmon, a process constrained by high costs, batch-to-batch variability, and limited purity. Furthermore, reliance on natural resources poses environmental sustainability concerns and limits scalability to meet growing market demand.
RJMPDRN® REC addresses these challenges by utilizing engineered bacterial strains to replicate target PDRN fragments, enabling controlled synthesis while maintaining reproducible quality and minimizing ecological impact.
This recombinant approach allows for precise design of functional sequences, resulting in nucleic acid products tailored for specific bioactive effects. The molecular weight and structural consistency of the fragments are strictly controlled, enhancing both uniformity and skin penetration. As an animal-free ingredient, RJMPDRN® REC aligns with global regulatory standards, expanding market acceptability in sensitive regions. The production process follows strict quality standards, using scalable fermentation and purification methods that deliver consistent quality, high purity, and a reliable supply—addressing the cost, supply chain, and environmental challenges of conventional extraction.
Physicochemically, RJMPDRN® REC is a white, water-soluble powder composed of DNA with minor RNA, derived from salmon PDRN sequences, and exhibits a pH range of 5.0–9.0. It is classified as a cosmetic-grade ingredient suitable for use in high-end emulsions, creams, eye patches, masks, and other premium skincare formulations. In vitro studies have demonstrated its safety and efficacy at concentrations of 100–200 μg/mL, supporting cell proliferation and anti-inflammatory activity without cytotoxicity.
Efficacy studies further highlight the superior bioactivity of RJMPDRN® REC. It significantly enhances fibroblast migration, achieving a proliferation rate of 131% at 41 hours compared with controls. In terms of collagen synthesis, RJMPDRN® REC promotes human type I collagen by 1.5 times and type III collagen by 1.1 times relative to controls, outperforming conventional salmon-derived PDRN. Additionally, it substantially inhibits inflammatory mediators such as TNF-α and IL-6. When combined with sodium hyaluronate, , RJMPDRN® REC exhibits synergistic effects, increasing cell migration, indicating strong potential for collaborative formulations in regenerative and anti-aging skincare.
In summary, RJMPDRN® REC embodies a technological leap from traditional extraction to biotechnological synthesis, providing a reproducible, high-purity, and sustainable alternative for high-end skincare formulations. Its demonstrated bioactivity, safety profile, and scalability position it as a strategic ingredient for cosmetic products targeting anti-aging, skin repair, and overall skin health, fully aligning with the evolving demand for sustainable and scientifically validated cosmetic ingredients.
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Post time: Aug-28-2025