For decades, PDRN has relied on extraction from salmon reproductive cells, creating inherent constraints in supply stability, DNA sequence randomness, and purity control.
Our RJMPDRN® REC(World First Recombinant PDRN) overcomes these limitations through advanced bioengineering. Free from animal sources and built on controlled biosynthesis, this innovation uses biosynthesis technology. Specific PDRN sequences are introduced via recombinant vectors and replicated through microbial fermentation. This eliminates dependence on fish-derived materials while ensuring alignment with EU, U.S., and global regulatory standards. The product remains DNA-based, biologically authentic, and vegan.
Unlike conventional PDRN (obtained via non-selective extraction), recombinant technology enables full control over DNA sequence and fragment length. Short-chain sequences target anti-inflammatory applications; medium-to-long-chain sequences optimize collagen regeneration and skin repair. Industrial-scale scalability is achieved through optimized heat-shock transformation, high-efficiency competent cell preparation technology and multi-step purification, consistently delivering biomedical-grade purity (≥99.5%).
A 28-day human efficacy study was conducted on 31 subjects using a 0.1% RJMPDRN® REC aqueous solution.
Day 14 Results (in vivo):
TEWL ↓9.58% (p<0.001)
Elasticity (R2) ↑19.33% (p<0.001)
Firmness (F4) ↓13.16% (p<0.001)
Erythema Index ↓7.11% (p<0.001)
Wrinkle count ↓40.00% (p<0.001)
Wrinkle area ↓6.97% (p<0.001)
Wrinkle length ↓8.14% (p=0.005)
Day 28 Results (in vivo):
TEWL ↓17.37% (p<0.001)
Elasticity (R2) ↑30.11% (p<0.001)
Firmness (F4) ↓19.83% (p<0.001)
Erythema Index ↓12.40% (p<0.001)
Wrinkle count ↓46.67% (p<0.001)
Wrinkle area ↓7.44% (p<0.001)
Wrinkle length ↓11.44% (p=0.002)
RJMPDRN® REC(World First Recombinant PDRN) delivers the same skin repair and regeneration mechanisms as traditional PDRN, but with guaranteed consistency, vegan sourcing, and regulatory safety. It is a technological upgrade – not merely a substitute.
Post time: Mar-20-2026