Unveiling the science and sustainability behind our salmon- and plant-derived DNA ingredients
Since first being approved in Italy in 2008 for tissue repair, PDRN (polydeoxyribonucleotide) has evolved into a gold-standard ingredient for skin regeneration in both medical and cosmetic fields, due to its remarkable regenerative effects and safety profile. Today, it is widely used in cosmetic products, medical beauty solutions, and daily skincare formulations.
PromaCare PDRN series harnesses the power of DNA sodium — a next-generation ingredient backed by science and trusted in both skin clinics and cosmetic innovation. From skin repair to inflammation reduction, our PDRN range activates the skin’s natural ability to heal and regenerate. With both marine and botanical sources available, we offer effective, safe, and versatile options to match modern formulation needs.
Salmon-Derived PromaCare PDRN: Proven Efficacy in Skin Recovery
Extracted from salmon sperm, PromaCare PDRN is purified through ultrafiltration, enzymatic digestion, and chromatography to reach over 98% similarity to human DNA. It activates the adenosine A₂A receptor to initiate a cascade of cellular repair signals. This mechanism boosts the production of epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF), which help remodel damaged skin, encourage collagen and elastin regeneration, and stimulate capillary formation for improved nutrient flow.
In addition to improving skin texture and resilience, PromaCare PDRN also reduces inflammation and oxidative damage caused by UV rays. It helps repair acne-prone and sensitive skin, improves dullness, and supports the rebuilding of the skin’s barrier from within.
Plant-Based Innovation: LD-PDRN and PO-PDRN for Eco-Conscious Efficacy
For brands seeking cleaner, sustainable options without compromising performance, Uniproma offers two plant-derived PDRNs:
PromaCare LD-PDRN (Laminaria Digitata Extract; Sodium DNA)
Extracted from brown algae (Laminaria japonica), this ingredient delivers multi-layered skin benefits. It promotes skin regeneration by enhancing fibroblast activity and encouraging the secretion of EGF, FGF, and IGF. It also increases VEGF levels to support new capillary formation.
Its brown alginate oligosaccharide structure stabilizes emulsions, inhibits inflammation by blocking leukocyte migration via selectins, and suppresses apoptosis by regulating Bcl-2, Bax, and caspase-3 activity. The ingredient’s polymer structure allows for excellent water retention, soothing, and film-forming capabilities — ideal for repairing damaged, dehydrated, or irritated skin.
PromaCare PO-PDRN (Platycladus Orientalis Leaf Extract; Sodium DNA)
This plant-based PDRN is derived from Platycladus Orientalis and provides antibacterial, anti-inflammatory, and moisturizing effects. Volatile oils and flavonoids in the extract disrupt bacterial membranes and inhibit nucleic acid synthesis, while anti-inflammatory agents suppress the NF-κB pathway to reduce redness and irritation.
Its hydrating polysaccharides form a water-binding layer on the skin, stimulating natural moisturizing factor synthesis and strengthening the barrier. It also supports collagen production and tightens pores — contributing to smoother, more elastic skin.
Both botanical PDRNs are extracted directly from plant cells using a strict purification process, offering high stability, safety, and a clean-label solution for high-performance skincare.
Science-Driven, Future-Focused
In vitro results show 0.01% of PDRN boosts fibroblast proliferation at levels comparable to 25 ng/mL of EGF. Moreover, 0.08% PDRN significantly increases collagen synthesis, especially when processed to a lower molecular weight.
Whether you’re formulating for barrier repair, anti-aging, or inflammation care, Uniproma’s PromaCare PDRN range offers powerful options supported by clear mechanisms and flexible sourcing.
Salmon- or plant-based — the choice is yours. The results are real.
Post time: Jun-10-2025