Innovative raw material design

Molecular self-assembly

--a frontier green chemistry without bond breaking and reconnection

The core principle of molecular self-assembly:

1. Like attracts like - driving similar substances to gather and arrange each other, and substances with complementary properties to attract each other.

2. The lowest energy—matter movement and molecular behavior will tend to the most stable state. It is a way for molecular groups to be arranged into advanced structures.

Molecular self-assembly-designability, the CP structure between molecules can significantly improve biological activity:

1. Each molecule has its unique structure and functional properties, and it is difficult to achieve synergy and precise treatment based on free mixing at the formulation level.

2. There are still many molecules with excellent biological activity that have severely limited their absorption and application due to their negative characteristics.

3. The active substances of traditional Chinese medicine are very particular about "the monarch, ministers and assistants", rather than a hodgepodge of the more the better.

Supramolecular structure modification and optimization analysis process model:

1. Computer-aided high-throughput screening for rapid screening of suitable precursors from the Cambridge Crystal Data Center.

2. Use density functional theory to study the supramolecular structure and assembly properties determined by intermolecular forces, and determine which supramolecular type is the formation trend.

3. By analyzing the reaction conditions and difficulty, the supramolecular structure was optimized.

4. Calculation of various properties of supramolecules, including electrical, optical and thermodynamic properties.

5. Calculation of spectral properties such as molecular spectrum and energy spectrum.

6.Through molecular docking technology, the interaction sites between supramolecular raw materials and target proteins are predicted, and the interaction mechanism between molecules is described in depth.

Supramolecular eutectic/Ionic salt technology

Technical features: the industry's first, screening the best CP components of active components for eutectic strengthening

Advantages: reduce irritation, enhance solubility, improve functionality, promote permeability, improve stability

Examples of ingredients: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

The natural active ingredients taken from the catalog of cosmetic raw materials, after verification tests such as quantum chemical simulation, high-throughput screening, Gaussian optimization, KingDraw, MestReNova, FTIR, and NMR, the obtained products have excellent three-dimensional crystal structure, good stability, High purity, less impurities. It can effectively solve the application pain points of functional ingredients in food, medicine and cosmetics, and improve the bioavailability and safety of functional ingredients.

Supramolecular activity extraction technology

echnical features: The industry's first, the combination of molecular imprinting technology and natural supramolecular solvents, efficient extraction of plant active ingredients

Advantages: Targeted extraction, the extraction efficiency is increased by 5 times compared with alcohol extraction, and water extraction is increased by 20 times; no separation, cost reduction, Penetration-promoting ingredients Examples: olive (oleuropein, hydroxytyrosol), rhodiola, medicinal Phyloporus, white water lily, micrococcus

Natural deep eutectic solvent (NaDES): It was first discovered by scientists in the analysis of plant metabolomics. During certain developmental stages of plants (germination, cryopreservation), cells will spontaneously form a highly viscous liquid independent of water and lipids, similar to a mixture of eutectics.

Based on modern green separation technology, integrated membrane technology, complemented by ultrasonic / microwave enhancement technology to achieve low temperature, targeted, high ciency, high quality and green extraction of active components.Through the natural supramolecular solvent as the efficacy extraction solvent, it solves many problems such as low efficiency, high cost and difficulty in waste liquid recovery of traditional phytochemical extraction.The extracted supramolecular solvents have been selected for their performance. The selected supramolecular solvent has stable performance and enhanced solubility of active ingredients, also the extraction efficiency can be increased by 20 times.

Supramolecular synergistic penetration technology

Technical features: The industry's first, through the supramolecular solvent synergistically promote the penetration of macromolecules/water-soluble/difficult to absorb ingredients

Technical advantages: improved stability, non-destructive and efficient penetration enhancement, synergistic effect, directional enrichment in the dermis, and bioavailability increased by 5-7 times Ingredients examples: collagen, Bosein, blue copper peptide, hexapeptide, compound peptide , β-glucan.

Since the molecular weight of the peptide is still relatively large compared to other active ingredients, the skin penetration is relatively low. Some penetration-enhancing means are needed to improve the penetration-enhancing absorption effect of the peptide, so as to achieve low concentration and high efficacy, and achieve better anti-aging efficacy.

In response to the industry sore point of poor penetration, high hydrophilicity and low bioavailability of traditional macromolecules, the JUNAS Time Particle products synthesis via quantum chemistry assisted, can directly reach the epidermis and dermis of the skin through trans-cellular,intercellular and follicular sweat ductchannels. Without damaging the skin structure.The bioavailability of the product is increased by 5 times, including more than 45% in the dermis,without damaging the skin structure.The penetration effect and dwell time have been achieved milestone improvements.This is the first of its kind in the industry.

Supramolecular biocatalysis technology

Bioenzyme-directed catalysis: supramolecular solvents are used as substrates to enhance enzyme activity, enhance chiral selection, and achieve high purity

Engineering fennel green fermentation: select characteristic plants, enhance the content of active ingredients, anhydrous formula, improve the overall efficacy

Reverse micellar fermentation technology: screening characteristic strains, fermenting vegetable oil, more effects, improving skin feel and enhancing absorption

Based on recombinant gene technology, one-step gene cloning technology and high-density bioenzyme catalytic technology, genetically engineered bacteria are used as catalytic carriers to realize the large-scale production of active substances:

Under the supramolecular solvent system, the enzyme shows higher activity, selectivity and stability,high utilization of substrate raw materials, less pollution in the production process, mild reaction conditions, higher safety performance and production performance.

Reverse micelle fermentation technology:

 selected natural oils with Chinese characteristics lP are spontaneously designed to produce surfactants under the action of genetically engineered bacteria.lt is assembled as the carrier of the anti-micellar bundle to realize the anti-micellar bundle wrapping of water-soluble active ingredients to achieve rich application scenarios, ultimate skin experience, and remarkable efficacy, experience, and significant efficacy.

Supramolecular microencapsulation technology

Technical features: liposome encapsulation, targeted release of dermal cells, targeted release of hair follicles, and responsive release of inflammatory factors

Advantages: Nanoization, precise delivery, long-acting sustained release, reducing irritation, improving stability, and promoting permeability

Examples of ingredients: astaxanthin, glabridin, vitamin A, blue copper peptide, biotin, ceramide, plant essential oil

Supramolecular microencapsulation technology is based on liposome, fat emulsion, ionic liquid stabilization technology, dermal cell targeted release technology, hair follicle targeted release technology, and inflammatory factor responsive release technology.By creating artificial transport channels, the product can deliver the active ingredients precisely. lt has excellent transdermal absorption rate, long dwell time and good stability in skin target location. It also has low cost and high efficacy applications in the field of cosmetics, functional foods and pharmaceuticals.

Peptide hierarchical self-assembly technology

Technical features: the industry's first, targeted regulation of the multilevel structure of amino acid chains and polypeptides, self-assembled short peptides, supramolecular polypeptides

Technical direction: Improve amphiphilicity, enhance stability and heat resistance, reduce toxicity and immune stress, promote absorption, and synergize

Examples of ingredients: supramolecular carnosine, yeast protein peptide

Self-assembly of proteins and peptides is not only ubiquitous in life systems, but also an excellent endogenous substance for the human body, and also one of the effective means for synthesizing nano-biological materials. The peptide self-assembly process is a hierarchical assembly process, and the "polar amino acid zipper structure" is a new type of super-secondary structure, which is conducive to the hierarchical assembly of peptides to form ordered aggregates.

Directional regulation of the size of short peptides can be achieved by changing the hydrophobicity and side chain branching of hydrophobic residues.

Based on Shinehigh Innovation's unique ProteinDataBank (PDB) database, combine with systematic experimental observation, molecular dynamics and quantum chemistry calculations to analyze the structure of peptide molecules, and then match them with high-throughput self-assembly molecules.Modulation of the type, number and relative position of amino acids between peptide molecules to change their specific folding structure, thereby improving the ability of the molecule to self-assemble.Realize the targeted regulation of peptides. The self-assembled peptide has excellent amphiphilicity and symmetry, which greatly improves peptide stability, transdermal ability and bioavailability.